Create Health - A Strategic Centre for Translational Cancer Research

CREATE Health is a Strategic Centre for Translational Cancer research located in the Biomedical Centre in Lund. The Centre is funded by the Swedish Foundation for Strategic Research. By integrating clinicians and researchers from Lund University Hospital with researchers from the Faculties of Medicine, Natural Sciences and Engineering using a superbly equipped and integrated “omics” platform, concentrated in a single area, a centre unique in its kind has been created.

The vision of CREATE Health is to use an integrative approach to develop novel diagnostics and therapeutics, based on identified markers and molecular signatures and to create a substantial social impact for the patient, through direct application of research for selection of an optimal, individually-based, cancer treatment.

Our most important achievements during last year was that we

• Discovered a novel histological marker for cyclin D1 positive and negative mantle cell lymphomas that will improve the diagnosis.
• For the first time have identified a gene profile of breast cancer which is far more effective than previous markers as an indicator of which treatment to use
• Have found 25 antibodies which distinguish malignant from benign ovarian cancer. The antibodies have been tested in tissue microarray and will prove useful for direct clinical usage and will be tested for developing a serum-based screen.
• For the first time have identified a serum protein signature which can distinguish between pancreatic cancer patients and healthy individuals and another predicting survival in these patients
• Using gene expression profiling of 650 sporadic and hereditary breast cancers we have revealed distinct subtypes of the disease. In addition tiling BACarray CGH analysis shows that gene expression subtypes of breast cancer also have distinct genomic aberrations.